Appeared
asymptomatic. Another serological study detected SARS-CoV-2 neutralizing
antibodies in cat serum samples collected in Wuhan after the outbreak of
COVID-19, providing evidence for SARS-CoV-2 infection in cat populations in Wuhan,
although the possibility of transmission of SARS-CoV-2 from cats to humans is
currently uncertain46.
Receptor
usage and pathogenesis
SARS-CoV-2
uses the same receptor as SARS-CoV, angiotensin-converting enzyme 2 (ACE2)
11,47. In addition to human ACE2 (hACE2), SARS-CoV-2 also recognizes ACE2 from
pig, ferret, rhesus monkey, nutmeg, cat, pangolin, rabbit and dog11,43,48,49.
The widespread receptor usage of SARS-CoV-2 suggests that it may have a wide
host range, and the varying efficiency of ACE2 usage in different animals may
indicate their different susceptibility to SARS-CoV-2 infection. The S1 subunit
of a coronavirus is further divided into two functional regions, an N-terminal
domain and a C-terminal domain. Structural and biochemical analyzes identified
a region of 211 amino acids (amino acids 319–529) in the C-terminal S1 region
of SARS-CoV-2 as the RBD, which has a key role in virus entry and is the target
of neutralizing antibodies 50,51 ( FIG. 3a). The RBM mediates contact with the
ACE2 receptor (amino acids 437-507 of the SARS-CoV-2 S protein), and this
region in SARS-CoV-2 differs from that of SARS-CoV in the five residues
critical to
Evaluated
intrauterine vertical transmission of COVID-19 infection in nine infants born
in
infected
mothers, they found that none of the
infants
tested positive for the virus.45 Likewise, there was no evidence of
intrauterine infection
caused
by vertical transmission in the SARS and MERS epidemics.4 43
The
CDC maintains that infants born to mothers with confirmed COVID-19 are
considered persons under investigation (PUI) and should be temporarily
separated from the mother and isolated.46
Breastfeeding and infant care
The
data available to date are limited and cannot confirm whether or not COVID-19
can be transmitted through breast milk.40 Evaluation of the presence of
COVID-19 in breast milk samples from six patients showed a negative result.45
The CDC points out that in the case of confirmed or suspected COVID-19
infection, the decision about whether or how to initiate or continue
breastfeeding should be made by the mother in collaboration with family and
health professionals.47 Careful precautions should be taken by the mother to
prevent transmission of the disease to her infant through respiratory droplets
during breastfeeding. This includes wearing a face mask and hand practice FOR good Heart.
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